HP to one

Available for New Game Plus in Lizardmageddon: Brazil, liquid nitrogen grenades freeze their victims upon impact. Once frozen, all victims have their Hit Points reduced to 1, thus being shattered by a follow-up attack; however, such ammunition is effetive only against generic enemies (since they aren't invulnerable to one-hit kills).

Best part: unlimited ammo.

The effect was first inspired by Castlevania 3: Dracula's Curse, with Sypha Belnades being able to freeze and shatter all enemies (except for bosses).

As for Alfred from Bloodstained: Curse of the Moon, his freezing attack was another inspiration, just as demonstrated below.

 Lenin will do the same to most of his victims!